Protein profile

VK055_0201

type VI secretion lipofamily protein

Genome: KpATCC43816

Gene: sciN2 AIK78829.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPR4
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Amino acids 180
Annotations 0
Features 17
PDB binders 0
Druggability 0.207

Overview

Basic information about this protein and its source genome.

Accession
VK055_0201
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
sciN2 AIK78829.1
Status
annotated
Amino acids
180
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
85.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.207
Structure A0A0H3GPR4
Pocket Pocket 3
P2Rank
Structure A0A0H3GPR4
Pocket No pockets
ColabFold model
FPocket 0.505 · Pocket 8
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 39 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
9 174 PANTHER PTHR37625 OUTER MEMBRANE LIPOPROTEIN-RELATED
9 174 InterPro IPR017734 Type VI secretion system, lipoprotein SciN
1 36 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
14 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
47 180 Gene3D G3DSA:2.60.40.4150 Type VI secretion system, lipoprotein SciN
47 180 InterPro IPR038706 Type VI secretion protein SciN-like superfamily
30 180 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
14 156 NCBIfam TIGR03352 type VI secretion system lipoprotein TssJ
14 156 InterPro IPR017734 Type VI secretion system, lipoprotein SciN
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
1 26 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 29 SignalP_EUK SignalP-noTM SignalP-noTM
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
49 169 Pfam PF12790 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113
49 169 InterPro IPR017734 Type VI secretion system, lipoprotein SciN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPR4
AlphaFold — — full sequence — Viewing
ColabFold VK055_0201
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.207