Protein profile

VK055_0274

hypothetical protein

Genome: KpATCC43816

Gene: AIK78900.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU82
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Amino acids 241
Annotations 0
Features 7
PDB binders 0
Druggability 0.724

Overview

Basic information about this protein and its source genome.

Accession
VK055_0274
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78900.1
Status
annotated
Amino acids
241
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
84.232
DEG E-value
5.76e-156
Localization
OuterMembrane
ColabFold pLDDT
85.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.724
Structure A0A0H3GU82
Pocket Pocket 8
P2Rank 0.675
Structure A0A0H3GU82
Pocket Pocket 1
ColabFold model
FPocket 0.977 · Pocket 4
P2Rank 0.947 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 87 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
1 14 Phobius SIGNAL_PEPTIDE Signal peptide region
11 14 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
15 241 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
36 240 Pfam PF04338 Protein of unknown function, DUF481
36 240 InterPro IPR007433 Protein of unknown function DUF481
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU82
AlphaFold — — full sequence — Viewing
ColabFold VK055_0274
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.724
16 0.641
19 0.347

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.46 0.391
2 6.13 0.305
3 4.51 0.193
4 2.11 0.048