Protein profile

VK055_0309

periplasmic binding family protein

Genome: KpATCC43816

Gene: AIK78935.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU56
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Amino acids 322
Annotations 0
Features 9
PDB binders 0
Druggability 0.421

Overview

Basic information about this protein and its source genome.

Accession
VK055_0309
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78935.1
Status
annotated
Amino acids
322
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.421
Structure A0A0H3GU56
Pocket Pocket 1
P2Rank 0.84
Structure A0A0H3GU56
Pocket Pocket 1
ColabFold model
FPocket 0.779 · Pocket 1
P2Rank 0.78 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 29 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
6 314 PANTHER PTHR30535 VITAMIN B12-BINDING PROTEIN
3 130 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
32 322 ProSiteProfiles PS50983 Iron siderophore/cobalamin periplasmic-binding domain profile.
32 322 InterPro IPR002491 ABC transporter periplasmic binding domain
140 321 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
257 277 Coils Coil Coil
33 297 Pfam PF01497 Periplasmic binding protein
33 297 InterPro IPR002491 ABC transporter periplasmic binding domain
29 316 SUPERFAMILY SSF53807 Helical backbone metal receptor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU56
AlphaFold — — full sequence — Viewing
ColabFold VK055_0309
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.421
5 0.085
15 0.052
6 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.4 0.84
2 2.6 0.061
3 0.91 0.004
4 0.62 0.001