Protein profile

VK055_0322

feS assembly protein SufD

Genome: KpATCC43816

Gene: AIK78948.1 sufD Structure source: AlphaFold + ColabFold UniProt A0A0H3GUU6
Export view
Amino acids 424
Annotations 1
Features 8
PDB binders 0
Druggability 0.331

Overview

Basic information about this protein and its source genome.

Accession
VK055_0322
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78948.1 sufD
Status
annotated
Amino acids
424
Structure source
AlphaFold + ColabFold
GO
GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
34.25
Localization
Cytoplasmic
ColabFold pLDDT
94.58

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.331
Structure A0A0H3GUU6
Pocket Pocket 3
P2Rank 0.054
Structure A0A0H3GUU6
Pocket Pocket 1
ColabFold model
FPocket 0.279 · Pocket 3
P2Rank 0.171 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 102 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
171 394 Pfam PF01458 SUF system FeS cluster assembly, SufBD
171 394 InterPro IPR000825 SUF system FeS cluster assembly, SufBD
24 419 PANTHER PTHR43575 PROTEIN ABCI7, CHLOROPLASTIC
24 419 InterPro IPR011542 SUF system FeS cluster assembly, SufD
12 421 SUPERFAMILY SSF101960 Stabilizer of iron transporter SufD
12 421 InterPro IPR037284 SUF system FeS cluster assembly, SufBD superfamily
133 410 NCBIfam TIGR01981 Fe-S cluster assembly protein SufD
133 410 InterPro IPR011542 SUF system FeS cluster assembly, SufD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUU6
AlphaFold — — full sequence — Viewing
ColabFold VK055_0322
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.203
1 0.093
5 0.008
19 0.003

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.44 0.054
2 2.4 0.052
3 1.95 0.034
4 1.93 0.033
5 1.74 0.026