Protein profile

VK055_0345

sugar (and other) transporter family protein

Genome: KpATCC43816

Gene: AIK78971.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUS7
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Amino acids 386
Annotations 5
Features 54
PDB binders 0
Druggability 0.896

Overview

Basic information about this protein and its source genome.

Accession
VK055_0345
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78971.1
Status
annotated
Amino acids
386
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046943 Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.714
Human E-value
9.63e-08
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
52.174
DEG E-value
1.81e-83
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.896
Structure A0A0H3GUS7
Pocket Pocket 19
P2Rank 0.792
Structure A0A0H3GUS7
Pocket Pocket 1
ColabFold model
FPocket 0.84 · Pocket 21
P2Rank 0.738 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 23 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046943 Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

Sequence Features

Domain/signature hits from InterPro and related databases.

54 records
Show feature table
Start End DB Term Name
354 376 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
128 150 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
116 126 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
148 152 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
269 286 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
241 258 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
99 124 ProSitePatterns PS00217 Sugar transport proteins signature 2.
99 124 InterPro IPR005829 Sugar transporter, conserved site
3 383 PANTHER PTHR23508 CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG
378 386 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 15 SignalP_EUK SignalP-TM SignalP-TM
293 313 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 380 CDD cd17365 MFS_PcaK_like
259 269 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
320 338 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
154 176 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
127 147 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
174 193 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
41 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
199 384 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
199 384 InterPro IPR036259 MFS transporter superfamily
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 31 Phobius SIGNAL_PEPTIDE Signal peptide region
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
32 40 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
68 88 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
270 287 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
288 292 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 381 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
3 381 InterPro IPR020846 Major facilitator superfamily domain
339 357 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
94 115 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
153 173 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
222 240 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
201 223 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
320 339 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 188 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
1 188 InterPro IPR036259 MFS transporter superfamily
68 90 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 284 Pfam PF07690 Major Facilitator Superfamily
8 284 InterPro IPR011701 Major facilitator superfamily
314 319 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
358 377 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
94 116 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
291 313 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
194 221 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
62 67 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
14 31 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
3 382 SUPERFAMILY SSF103473 MFS general substrate transporter
3 382 InterPro IPR036259 MFS transporter superfamily
238 260 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
89 93 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUS7
AlphaFold — — full sequence — Viewing
ColabFold VK055_0345
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
19 0.896

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.27 0.75
2 3.0 0.098
3 2.21 0.053
4 1.57 0.024