Protein profile

VK055_0381

CRISPR type I-E/ECOLI-associated protein CasB/Cse2

Genome: KpATCC43816

Gene: AIK79007.1 casB Structure source: AlphaFold + ColabFold UniProt A0A0C7KCS0
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Amino acids 188
Annotations 0
Features 7
PDB binders 0
Druggability 0.017

Overview

Basic information about this protein and its source genome.

Accession
VK055_0381
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79007.1 casB
Status
annotated
Amino acids
188
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
88.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.017
Structure A0A0C7KCS0
Pocket Pocket 17
P2Rank 0.014
Structure A0A0C7KCS0
Pocket Pocket 1
ColabFold model
FPocket 0.133 · Pocket 7
P2Rank 0.002 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 3 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
38 172 Pfam PF09485 CRISPR-associated protein Cse2 (CRISPR_cse2)
38 172 InterPro IPR013382 CRISPR-associated protein Cse2
27 173 NCBIfam TIGR02548 type I-E CRISPR-associated protein Cse2/CasB
27 173 InterPro IPR013382 CRISPR-associated protein Cse2
34 173 CDD cd09731 Cse2_I-E
12 186 Gene3D G3DSA:1.10.520.40 -
12 186 InterPro IPR038287 Cse2 superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0C7KCS0 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7KCS0
AlphaFold — — full sequence — Viewing
ColabFold VK055_0381
ColabFold — — full sequence — Loaded