Protein profile

VK055_0382

CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI

Genome: KpATCC43816

Gene: cas6e AIK79008.1 Structure source: AlphaFold + ColabFold UniProt A0A0C7K7U4
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Amino acids 200
Annotations 0
Features 9
PDB binders 0
Druggability 0.644

Overview

Basic information about this protein and its source genome.

Accession
VK055_0382
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
cas6e AIK79008.1
Status
annotated
Amino acids
200
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.644
Structure A0A0C7K7U4
Pocket Pocket 4
P2Rank 0.166
Structure A0A0C7K7U4
Pocket Pocket 1
ColabFold model
FPocket 0.56 · Pocket 2
P2Rank 0.176 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
3 193 CDD cd09727 Cas6_I-E
5 193 Pfam PF08798 CRISPR associated protein
5 193 InterPro IPR010179 CRISPR-associated protein Cse3
2 193 NCBIfam TIGR01907 type I-E CRISPR-associated protein Cas6/Cse3/CasE
2 193 InterPro IPR010179 CRISPR-associated protein Cse3
80 193 SUPERFAMILY SSF117987 CRISPR-associated protein
1 193 SMART SM01101 CRISPR_assoc_2
1 193 InterPro IPR010179 CRISPR-associated protein Cse3
81 193 Gene3D G3DSA:3.30.70.1210 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7K7U4
AlphaFold — — full sequence — Viewing
ColabFold VK055_0382
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.644
2 0.021
3 0.004
9 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.64 0.166
2 3.66 0.111
3 2.45 0.054
4 1.07 0.006