Protein profile

VK055_0384

CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI

Genome: KpATCC43816

Gene: AIK79010.1 cas5e Structure source: AlphaFold + ColabFold UniProt A0A333GE17
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Amino acids 231
Annotations 3
Features 8
PDB binders 0
Druggability 0.536

Overview

Basic information about this protein and its source genome.

Accession
VK055_0384
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79010.1 cas5e
Status
annotated
Amino acids
231
Structure source
AlphaFold + ColabFold
GO
GO:0043571 Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0051607 Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.536
Structure A0A333GE17
Pocket Pocket 2
P2Rank 0.746
Structure A0A333GE17
Pocket Pocket 1
ColabFold model
FPocket 0.732 · Pocket 1
P2Rank 0.626 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043571 Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0051607 Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
2 41 NCBIfam TIGR02593 CRISPR-associated protein Cas5
2 41 InterPro IPR013422 CRISPR-associated protein Cas5, N-terminal
1 230 Gene3D G3DSA:3.30.70.2660 -
2 222 Pfam PF09704 CRISPR-associated protein (Cas_Cas5)
2 222 InterPro IPR021124 CRISPR-associated protein, Cas5
2 173 CDD cd09756 Cas5_I-E
1 227 NCBIfam TIGR01868 type I-E CRISPR-associated protein Cas5/CasD
1 227 InterPro IPR010147 CRISPR-associated protein, CasD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A333GE17
AlphaFold — — full sequence — Viewing
ColabFold VK055_0384
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.536
1 0.255
7 0.004
4 0.003

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.22 0.746
2 1.53 0.018