Protein profile

VK055_0400

cytochrome c-type biogenesis protein CcmH

Genome: KpATCC43816

Gene: AIK79026.1 ccmH Structure source: AlphaFold + ColabFold UniProt A0A0H3GUN8
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Amino acids 148
Annotations 3
Features 17
PDB binders 0
Druggability 0.039

Overview

Basic information about this protein and its source genome.

Accession
VK055_0400
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79026.1 ccmH
Status
annotated
Amino acids
148
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion. GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
54.422
DEG E-value
1.77e-50
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.18

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.039
Structure A0A0H3GUN8
Pocket Pocket 4
P2Rank
Structure A0A0H3GUN8
Pocket No pockets
ColabFold model
FPocket 0.432 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 88 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.
  • GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
96 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
119 148 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
15 98 Gene3D G3DSA:1.10.8.640 Cytochrome C biogenesis protein
15 98 InterPro IPR038297 CcmH/CycL/Ccl2/NrfF domain superfamily
99 118 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 15 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
4 142 Pfam PF03918 Cytochrome C biogenesis protein
4 142 InterPro IPR005616 CcmH/CycL/Ccl2/NrfF family
11 15 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 15 Phobius SIGNAL_PEPTIDE Signal peptide region
1 15 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
15 95 FunFam G3DSA:1.10.8.640:FF:000001 Cytochrome c-type biogenesis protein
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
27 93 CDD cd16378 CcmH_N
2 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
16 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 126 PANTHER PTHR47870 CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMH

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUN8
AlphaFold — — full sequence — Viewing
ColabFold VK055_0400
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer