Protein profile

VK055_0404

alpha/beta hydrolase family protein

Genome: KpATCC43816

Gene: AIK79030.1 Structure source: AlphaFold + ColabFold UniProt A0A483NKJ7
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Amino acids 385
Annotations 0
Features 15
PDB binders 0
Druggability 0.945

Overview

Basic information about this protein and its source genome.

Accession
VK055_0404
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79030.1
Status
annotated
Amino acids
385
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.945
Structure A0A483NKJ7
Pocket Pocket 2
P2Rank 0.921
Structure A0A483NKJ7
Pocket Pocket 1
ColabFold model
FPocket 0.701 · Pocket 3
P2Rank 0.882 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
82 329 Pfam PF12697 Alpha/beta hydrolase family
82 329 InterPro IPR000073 Alpha/beta hydrolase fold-1
20 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
38 372 CDD cd12810 Esterase_713_like-3
68 248 PANTHER PTHR43194 HYDROLASE ALPHA/BETA FOLD FAMILY
60 369 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
60 369 InterPro IPR029058 Alpha/Beta hydrolase fold
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
26 385 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35 373 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
35 373 InterPro IPR029058 Alpha/Beta hydrolase fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483NKJ7
AlphaFold — — full sequence — Viewing
ColabFold VK055_0404
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.945

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.69 0.891