Protein profile

VK055_0436

mltA-interacting MipA family protein

Genome: KpATCC43816

Gene: AIK79062.1 Structure source: AlphaFold + ColabFold UniProt A0A4S7VW13
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Amino acids 255
Annotations 1
Features 13
PDB binders 0
Druggability 0.907

Overview

Basic information about this protein and its source genome.

Accession
VK055_0436
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79062.1
Status
annotated
Amino acids
255
Structure source
AlphaFold + ColabFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.907
Structure A0A4S7VW13
Pocket Pocket 26
P2Rank 0.964
Structure A0A4S7VW13
Pocket Pocket 1
ColabFold model
FPocket 0.981 · Pocket 1
P2Rank 0.924 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 27 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 18 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
1 18 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
29 255 Pfam PF06629 MltA-interacting protein MipA
29 255 InterPro IPR010583 MltA-interacting MipA
73 255 SUPERFAMILY SSF56925 OMPA-like
73 255 InterPro IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel
19 255 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 255 PANTHER PTHR38776 MLTA-INTERACTING PROTEIN-RELATED
3 255 InterPro IPR010583 MltA-interacting MipA
6 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A4S7VW13
AlphaFold — — full sequence — Viewing
ColabFold VK055_0436
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
26 0.907
25 0.851
1 0.788

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.97 0.929
2 15.6 0.757
3 11.34 0.607
4 2.58 0.074