Protein profile

VK055_0441

transposase family protein

Genome: KpATCC43816

Gene: AIK79067.1 Structure source: AlphaFold + ColabFold UniProt A0A377YXW2
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Amino acids 99
Annotations 3
Features 7
PDB binders 0
Druggability 0.086

Overview

Basic information about this protein and its source genome.

Accession
VK055_0441
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79067.1
Status
annotated
Amino acids
99
Structure source
AlphaFold + ColabFold
GO
GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.879
DEG E-value
2.3600000000000006e-58
Localization
Unknown
ColabFold pLDDT
89.02

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.086
Structure A0A377YXW2
Pocket Pocket 4
P2Rank
Structure A0A377YXW2
Pocket No pockets
ColabFold model
FPocket 0.156 · Pocket 2
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
1 21 MobiDBLite mobidb-lite consensus disorder prediction
11 96 SUPERFAMILY SSF46689 Homeodomain-like
11 96 InterPro IPR009057 Homeobox-like domain superfamily
12 78 Pfam PF01527 Transposase
12 78 InterPro IPR002514 Transposase IS3/IS911family
63 90 Coils Coil Coil
2 98 PANTHER PTHR33215 PROTEIN DISTAL ANTENNA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A377YXW2 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377YXW2
AlphaFold — — full sequence — Viewing
ColabFold VK055_0441
ColabFold — — full sequence — Loaded