Protein profile

VK055_0458

glyoxalase family protein

Genome: KpATCC43816

Gene: AIK79084.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUJ5
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Amino acids 127
Annotations 1
Features 9
PDB binders 0
Druggability 0.662

Overview

Basic information about this protein and its source genome.

Accession
VK055_0458
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79084.1
Status
annotated
Amino acids
127
Structure source
AlphaFold + ColabFold
GO
GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.662
Structure A0A0H3GUJ5
Pocket Pocket 5
P2Rank 0.055
Structure A0A0H3GUJ5
Pocket Pocket 1
ColabFold model
FPocket 0.35 · Pocket 5
P2Rank 0.076 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 125 PANTHER PTHR36113 LYASE, PUTATIVE-RELATED-RELATED
1 127 SUPERFAMILY SSF54593 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
1 127 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
2 125 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
2 125 InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
1 126 Gene3D G3DSA:3.10.180.10 -
1 126 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
2 127 ProSiteProfiles PS51819 Vicinal oxygen chelate (VOC) domain profile.
2 127 InterPro IPR037523 Vicinal oxygen chelate (VOC) domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUJ5
AlphaFold — — full sequence — Viewing
ColabFold VK055_0458
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.662
3 0.002
4 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.47 0.055
2 2.13 0.041