Metabolic network

VK055_0526

S-(hydroxymethyl)glutathione dehydrogenase/classIII alcohol dehydrogenase

Back to protein
Network centrality 0.01566 top 91.9%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing chokepoint reaction in Phenylalanine metabolism, no isoenzyme backup detected, more central than 91.9% of genes in this genome.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Phenylalanine metabolism Tryptophan metabolism

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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EC
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Pathway
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Genes
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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN-7657

EC 1.1.1.1 · RXN-7657 · reversible · no isoenzyme backup

isobutanol NAD+
⇌
H+ isobutanal NADH

RXN-7694

EC 1.1.1.1 · RXN-7694 · reversible · no isoenzyme backup

2-methylbutanol NAD+
⇌
H+ 2-methylbutanal NADH

RXN-7700

EC 1.1.1.1 · RXN-7700 · reversible · no isoenzyme backup

2-phenylethanol NAD+
⇌
H+ phenylacetaldehyde NADH

1.1.1.190-RXN

EC 1.1.1.190 · 1.1.1.190-RXN · reversible · no isoenzyme backup

(indol-3-yl)ethanol NAD+
⇌
H+ NADH (indol-3-yl)acetaldehyde

RXN-7693

EC 1.1.1.1 · RXN-7693 · reversible · no isoenzyme backup

3-methylbutanol NAD+
⇌
H+ 3-methylbutanal NADH

RXN-7706

EC 1.1.1.1 · RXN-7706 · reversible · no isoenzyme backup

methionol NAD+
⇌
3-(methylsulfanyl)propanal NADH H+

RXN-17884

EC 1.1.1.284 · RXN-17884 · not reversible · no isoenzyme backup

Producing chokepoint
S-nitrosoglutathione NADH H+
→
S-(hydroxysulfenamide)glutathione NAD+

Imported from KpATCC43816.sbml · 2026-07-09