Protein profile

VK055_0534

glucan biosynthesis protein D

Genome: KpATCC43816

Gene: AIK79157.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP27
Export view
Amino acids 551
Annotations 7
Features 26
PDB binders 0
Druggability 0.945

Overview

Basic information about this protein and its source genome.

Accession
VK055_0534
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79157.1
Status
annotated
Amino acids
551
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016051 The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
91.29

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.945
Structure A0A0H3GP27
Pocket Pocket 38
P2Rank 0.868
Structure A0A0H3GP27
Pocket Pocket 1
ColabFold model
FPocket 0.503 · Pocket 18
P2Rank 0.263 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 74 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016051 The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0051274 The chemical reactions and pathways resulting in the formation of beta-glucans.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
424 543 FunFam G3DSA:2.60.40.10:FF:000379 Glucans biosynthesis protein D
45 422 SUPERFAMILY SSF74650 Galactose mutarotase-like
45 422 InterPro IPR011013 Galactose mutarotase-like domain superfamily
1 538 PIRSF PIRSF006281 MdoG
1 538 InterPro IPR014438 Glucan biosynthesis protein MdoG/MdoD
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
44 421 Gene3D G3DSA:2.70.98.10 -
44 421 InterPro IPR014718 Glycoside hydrolase-type carbohydrate-binding
423 537 SUPERFAMILY SSF81296 E set domains
423 537 InterPro IPR014756 Immunoglobulin E-set
1 32 Phobius SIGNAL_PEPTIDE Signal peptide region
1 544 Hamap MF_01068 Glucans biosynthesis protein D [mdoD].
1 544 InterPro IPR023724 Glucan biosynthesis, MdoD
24 32 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 32 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 32 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 539 PANTHER PTHR30504 GLUCANS BIOSYNTHESIS PROTEIN
2 539 InterPro IPR014438 Glucan biosynthesis protein MdoG/MdoD
45 534 Pfam PF04349 Periplasmic glucan biosynthesis protein, MdoG
45 534 InterPro IPR007444 Glucan biosynthesis, periplasmic, MdoG C-terminal
33 551 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 32 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
424 544 Gene3D G3DSA:2.60.40.10 Immunoglobulins
424 544 InterPro IPR013783 Immunoglobulin-like fold
1 32 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP27
AlphaFold — — full sequence — Viewing
ColabFold VK055_0534
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
38 0.945
24 0.932
21 0.244

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.33 0.501
2 6.27 0.314
3 4.05 0.162
4 2.62 0.076
5 2.41 0.065