Protein profile

VK055_0540

hypothetical protein

Genome: KpATCC43816

Gene: AIK79163.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP23
Export view
Amino acids 222
Annotations 0
Features 11
PDB binders 0
Druggability 0.966

Overview

Basic information about this protein and its source genome.

Accession
VK055_0540
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79163.1
Status
annotated
Amino acids
222
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
70.721
DEG E-value
1.9e-122
Localization
Unknown
ColabFold pLDDT
87.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.966
Structure A0A0H3GP23
Pocket Pocket 1
P2Rank 0.905
Structure A0A0H3GP23
Pocket Pocket 1
ColabFold model
FPocket 0.956 · Pocket 1
P2Rank 0.858 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 59 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
24 222 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
5 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
30 213 Pfam PF11769 Protein of unknown function (DUF3313)
30 213 InterPro IPR021747 Protein of unknown function DUF3313
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP23
AlphaFold — — full sequence — Viewing
ColabFold VK055_0540
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.966

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 26.46 0.914
2 7.81 0.414
3 3.83 0.149