Protein profile

VK055_0598

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK79221.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYE5
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Amino acids 551
Annotations 3
Features 60
PDB binders 0
Druggability 0.924

Overview

Basic information about this protein and its source genome.

Accession
VK055_0598
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79221.1
Status
annotated
Amino acids
551
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
37.374
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.924
Structure A0A0H3GYE5
Pocket Pocket 6
P2Rank 0.807
Structure A0A0H3GYE5
Pocket Pocket 1
ColabFold model
FPocket 0.971 · Pocket 3
P2Rank 0.81 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records
Show feature table
Start End DB Term Name
96 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
84 94 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
493 512 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
352 374 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
61 83 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 31 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
349 536 CDD cd06261 TM_PBP2
349 536 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
513 523 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
376 386 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
63 83 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
311 352 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
77 265 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
77 265 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
366 550 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
366 550 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
546 551 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
523 545 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
468 490 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
286 310 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
142 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 265 SUPERFAMILY SSF161098 MetI-like
5 265 InterPro IPR035906 MetI-like superfamily
32 62 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
59 258 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
59 258 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
409 419 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
353 375 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
288 547 SUPERFAMILY SSF161098 MetI-like
288 547 InterPro IPR035906 MetI-like superfamily
524 545 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
349 543 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
349 543 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
117 135 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
420 437 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
159 182 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
95 116 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
183 208 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
209 240 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
488 492 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
239 261 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
465 487 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
241 261 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
387 408 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
185 207 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 269 Gene3D G3DSA:1.10.3720.10 -
8 269 InterPro IPR035906 MetI-like superfamily
262 285 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
136 158 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
59 219 CDD cd06261 TM_PBP2
59 219 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
5 548 PANTHER PTHR43357 INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCV
387 409 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
419 441 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
288 550 Gene3D G3DSA:1.10.3720.10 -
288 550 InterPro IPR035906 MetI-like superfamily
291 313 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
438 464 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYE5
AlphaFold — — full sequence — Viewing
ColabFold VK055_0598
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.924
2 0.754
26 0.22
11 0.205

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.44 0.753
2 5.49 0.261
3 2.62 0.076
4 2.22 0.054
5 2.21 0.053