Protein profile

VK055_0629

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK79252.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQB0
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Amino acids 314
Annotations 3
Features 33
PDB binders 0
Druggability 0.678

Overview

Basic information about this protein and its source genome.

Accession
VK055_0629
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79252.1
Status
annotated
Amino acids
314
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
35.849
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.678
Structure A0A0H3GQB0
Pocket Pocket 1
P2Rank 0.666
Structure A0A0H3GQB0
Pocket Pocket 1
ColabFold model
FPocket 0.252 · Pocket 3
P2Rank 0.722 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 36 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
197 229 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 105 Pfam PF19300 Binding-prot-dependent transport system membrane comp, N-term
1 105 InterPro IPR045621 ABC transporter type 1, GsiC-like, N-terminal domain
72 94 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
101 123 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
157 175 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
274 295 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
173 195 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
138 160 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
134 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 309 PANTHER PTHR43163 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
252 273 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
273 295 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
230 251 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
98 299 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
98 299 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
31 101 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
126 306 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
126 306 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
123 133 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
102 122 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
296 314 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
129 297 CDD cd06261 TM_PBP2
129 297 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
176 196 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
88 303 Gene3D G3DSA:1.10.3720.10 -
88 303 InterPro IPR035906 MetI-like superfamily
92 291 SUPERFAMILY SSF161098 MetI-like
92 291 InterPro IPR035906 MetI-like superfamily
230 252 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQB0
AlphaFold — — full sequence — Viewing
ColabFold VK055_0629
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.678
8 0.09
14 0.0
23 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.21 0.666
2 6.47 0.274
3 6.2 0.257
4 1.98 0.035
5 1.74 0.026