Protein profile

VK055_0639

metallo-beta-lactamase superfamily protein

Genome: KpATCC43816

Gene: AIK79262.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GY67
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Amino acids 283
Annotations 0
Features 19
PDB binders 0
Druggability 0.812

Overview

Basic information about this protein and its source genome.

Accession
VK055_0639
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79262.1
Status
annotated
Amino acids
283
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
46.324
DEG E-value
1.89e-82
Localization
Unknown
ColabFold pLDDT
94.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.812
Structure A0A0H3GY67
Pocket Pocket 1
P2Rank 0.92
Structure A0A0H3GY67
Pocket Pocket 1
ColabFold model
FPocket 0.881 · Pocket 1
P2Rank 0.931 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 49 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
21 242 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase
21 242 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
22 218 CDD cd07739 metallo-hydrolase-like_MBL-fold
34 218 Pfam PF00753 Metallo-beta-lactamase superfamily
34 218 InterPro IPR001279 Metallo-beta-lactamase
1 19 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 19 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
17 253 Gene3D G3DSA:3.60.15.10 -
17 253 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 283 NCBIfam NF040580 Vmh family MBL fold metallo-hydrolase
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
20 283 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
36 218 SMART SM00849 Lactamase_B_5a
36 218 InterPro IPR001279 Metallo-beta-lactamase
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
8 226 PANTHER PTHR42951 METALLO-BETA-LACTAMASE DOMAIN-CONTAINING
3 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GY67
AlphaFold — — full sequence — Viewing
ColabFold VK055_0639
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.812

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.07 0.877
2 1.45 0.019
3 1.08 0.007
4 1.08 0.007