Protein profile

VK055_0657

bestrophin, RFP-TM, chloride channel family protein

Genome: KpATCC43816

Gene: AIK79280.1 Structure source: Experimental + ColabFold UniProt W9BH30
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Amino acids 305
Annotations 3
Features 12
PDB binders 0
Druggability 0.975

Overview

Basic information about this protein and its source genome.

Accession
VK055_0657
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79280.1
Status
annotated
Amino acids
305
Structure source
Experimental + ColabFold
GO
GO:0005254 Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.57

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.975
Structure 6IVM
Pocket Pocket 1
P2Rank 0.128
Structure 6IVN
Pocket Pocket 1
ColabFold model
FPocket 0.682 · Pocket 2
P2Rank 0.054 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 74 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005254 Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
43 47 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 283 Pfam PF01062 Bestrophin, RFP-TM, chloride channel
2 283 InterPro IPR021134 Bestrophin-like
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
219 241 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 290 PANTHER PTHR33281 UPF0187 PROTEIN YNEE
6 290 InterPro IPR044669 Voltage-dependent anion channel-forming protein YneE/VCCN1/2-like
48 70 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 305 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
48 70 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

9 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6IVO
X-ray 2.45 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Viewing
PDB 6IVK
X-ray 2.65 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Loaded
PDB 6IVQ
X-ray 2.65 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Loaded
PDB 6IVJ
X-ray 2.77 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Loaded
PDB 6IVR
X-ray 2.80 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Loaded
PDB 6IVM
X-ray 2.95 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Loaded
PDB 6IVN
X-ray 3.10 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Loaded
PDB 6IVL
X-ray 3.40 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Loaded
PDB 6IVP
X-ray 3.80 Å A,B,C,D,E
96.4% 1-294
PDBe RCSB PDBj File
Loaded
ColabFold VK055_0657
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.819
61 0.434
4 0.41
36 0.24

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.61 0.805
2 7.71 0.408
3 7.11 0.369
4 6.21 0.31
5 6.03 0.297