Protein profile

VK055_0663

lamB porin family protein

Genome: KpATCC43816

Gene: AIK79286.1 Structure source: AlphaFold + ColabFold UniProt A0A094Y9K7
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Amino acids 427
Annotations 3
Features 13
PDB binders 0
Druggability 0.725

Overview

Basic information about this protein and its source genome.

Accession
VK055_0663
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79286.1
Status
annotated
Amino acids
427
Structure source
AlphaFold + ColabFold
GO
GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219 The process in which a carbohydrate is transported across a membrane.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
83.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.725
Structure A0A094Y9K7
Pocket Pocket 36
P2Rank 0.919
Structure A0A094Y9K7
Pocket Pocket 1
ColabFold model
FPocket 0.12 · Pocket 34
P2Rank 0.992 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0034219 The process in which a carbohydrate is transported across a membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
23 427 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
80 427 Pfam PF02264 LamB porin
80 427 InterPro IPR003192 Porin, LamB-type
49 69 MobiDBLite mobidb-lite consensus disorder prediction
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
16 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
31 427 Gene3D G3DSA:2.40.170.10 Porin, LamB type
31 427 InterPro IPR036998 Porin, LamB-type superfamily
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
65 427 SUPERFAMILY SSF56935 Porins
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A094Y9K7
AlphaFold — — full sequence — Viewing
ColabFold VK055_0663
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
36 0.725
7 0.599
1 0.593
4 0.202

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.45 0.802
2 15.48 0.754
3 14.64 0.729
4 4.74 0.208
5 3.57 0.132