Protein profile

VK055_0668

mg2+ transport protein

Genome: KpATCC43816

Gene: mgtC AIK79291.1 Structure source: AlphaFold + ColabFold UniProt A0A377V269
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Amino acids 162
Annotations 2
Features 27
PDB binders 0
Druggability 0.788

Overview

Basic information about this protein and its source genome.

Accession
VK055_0668
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
mgtC AIK79291.1
Status
annotated
Amino acids
162
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
38.889
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.788
Structure A0A377V269
Pocket Pocket 2
P2Rank 0.05
Structure A0A377V269
Pocket Pocket 1
ColabFold model
FPocket 0.943 · Pocket 1
P2Rank 0.038 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
12 31 PRINTS PR01837 MgtC/SapB protein signature
12 31 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
56 78 PRINTS PR01837 MgtC/SapB protein signature
56 78 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
31 49 PRINTS PR01837 MgtC/SapB protein signature
31 49 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
83 107 PRINTS PR01837 MgtC/SapB protein signature
83 107 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
60 77 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
60 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
97 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
78 96 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 136 PANTHER PTHR33778 PROTEIN MGTC
6 136 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
9 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
54 59 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
20 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
89 108 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
29 50 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 53 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
9 128 Pfam PF02308 MgtC family
9 128 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
125 162 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
24 32 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377V269
AlphaFold — — full sequence — Viewing
ColabFold VK055_0668
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.788
9 0.24

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.08 0.047