Protein profile

VK055_0689

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK79312.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GT47
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Amino acids 236
Annotations 3
Features 29
PDB binders 0
Druggability 0.712

Overview

Basic information about this protein and its source genome.

Accession
VK055_0689
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79312.1
Status
annotated
Amino acids
236
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
50.204
DEG E-value
2.2e-70
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.712
Structure A0A0H3GT47
Pocket Pocket 3
P2Rank 0.023
Structure A0A0H3GT47
Pocket Pocket 1
ColabFold model
FPocket 0.734 · Pocket 11
P2Rank 0.104 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 41 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
204 223 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
45 227 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
45 227 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
49 70 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
49 208 CDD cd06261 TM_PBP2
49 208 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
48 70 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
104 108 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
61 228 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
61 228 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
71 76 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
224 236 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
204 223 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
77 99 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
49 223 SUPERFAMILY SSF161098 MetI-like
49 223 InterPro IPR035906 MetI-like superfamily
1 39 Phobius SIGNAL_PEPTIDE Signal peptide region
109 128 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
77 103 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
36 231 Gene3D G3DSA:1.10.3720.10 -
36 231 InterPro IPR035906 MetI-like superfamily
129 203 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
10 235 PANTHER PTHR30151 ALKANE SULFONATE ABC TRANSPORTER-RELATED, MEMBRANE SUBUNIT
22 39 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
40 48 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT47
AlphaFold — — full sequence — Viewing
ColabFold VK055_0689
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.712
17 0.297
8 0.233
9 0.22

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.04 0.045
2 1.42 0.018
3 0.85 0.003