Protein profile

VK055_0708

bacterial regulatory helix-turn-helix, AraC family protein

Genome: KpATCC43816

Gene: AIK79331.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNL8
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Amino acids 104
Annotations 3
Features 15
PDB binders 0
Druggability 0.613

Overview

Basic information about this protein and its source genome.

Accession
VK055_0708
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79331.1
Status
annotated
Amino acids
104
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
28.409
Localization
Cytoplasmic
ColabFold pLDDT
97.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.613
Structure A0A0H3GNL8
Pocket Pocket 5
P2Rank
Structure A0A0H3GNL8
Pocket No pockets
ColabFold model
FPocket 0.414 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 13 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
65 103 Gene3D G3DSA:1.10.10.60 -
1 102 PANTHER PTHR11019 HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR
28 102 Pfam PF12833 Helix-turn-helix domain
28 102 InterPro IPR018060 DNA binding HTH domain, AraC-type
21 103 SMART SM00342 aracneu4
21 103 InterPro IPR018060 DNA binding HTH domain, AraC-type
4 55 SUPERFAMILY SSF46689 Homeodomain-like
4 55 InterPro IPR009057 Homeobox-like domain superfamily
5 64 Gene3D G3DSA:1.10.10.60 -
5 104 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
5 104 InterPro IPR018060 DNA binding HTH domain, AraC-type
59 102 SUPERFAMILY SSF46689 Homeodomain-like
59 102 InterPro IPR009057 Homeobox-like domain superfamily
58 99 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
58 99 InterPro IPR018062 HTH domain AraC-type, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNL8
AlphaFold — — full sequence — Viewing
ColabFold VK055_0708
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.613
7 0.297
2 0.056
4 0.0