Protein profile

VK055_0744

oxalate/formate antiporter

Genome: KpATCC43816

Gene: AIK79367.1 oxlT Structure source: AlphaFold + ColabFold UniProt A0A0H3GNI8
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Amino acids 418
Annotations 5
Features 50
PDB binders 4
Druggability 0.798

Overview

Basic information about this protein and its source genome.

Accession
VK055_0744
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79367.1 oxlT
Status
annotated
Amino acids
418
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0019532 The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0019531 Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.461
Human E-value
2.67e-07
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.798
Structure A0A0H3GNI8
Pocket Pocket 6
P2Rank 0.916
Structure A0A0H3GNI8
Pocket Pocket 1
ColabFold model
FPocket 0.381 · Pocket 9
P2Rank 0.941 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 18 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0019532 The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0019531 Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.

Sequence Features

Domain/signature hits from InterPro and related databases.

50 records
Show feature table
Start End DB Term Name
35 267 Pfam PF07690 Major Facilitator Superfamily
35 267 InterPro IPR011701 Major facilitator superfamily
276 295 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
15 405 CDD cd17353 MFS_OFA_like
164 168 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
37 55 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 410 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
1 410 InterPro IPR020846 Major facilitator superfamily domain
11 201 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
11 201 InterPro IPR036259 MFS transporter superfamily
216 412 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
216 412 InterPro IPR036259 MFS transporter superfamily
141 163 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 39 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
224 243 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
56 72 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
103 107 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
244 254 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 18 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
106 128 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
379 383 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
384 406 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 417 NCBIfam TIGR04259 oxalate/formate MFS antiporter
15 417 InterPro IPR026355 Oxalate/formate antiporter
84 102 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
319 339 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
340 358 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
255 275 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
19 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
224 243 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 414 SUPERFAMILY SSF103473 MFS general substrate transporter
15 414 InterPro IPR036259 MFS transporter superfamily
359 378 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
108 132 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
384 406 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 388 PANTHER PTHR11360 MONOCARBOXYLATE TRANSPORTER
296 313 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
407 418 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
314 318 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
141 163 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
189 223 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
169 188 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
355 377 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
133 140 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
173 192 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
54 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
84 102 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
253 272 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
73 83 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
318 340 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNI8
AlphaFold — — full sequence — Viewing
ColabFold VK055_0744
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.798

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.3 0.897
2 2.83 0.088
3 2.54 0.071
4 1.75 0.032
5 1.66 0.028

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
02Q
6ZGU
A0LNN5 164.2 Da LogP 2.01 TPSA 37.3 ✓ Ro5 ✓ Clean Cc1ccccc1CCC(=O)O
1HN
6ZGR
A0LNN5 188.2 Da LogP 2.24 TPSA 57.5 ✓ Ro5 ✓ Clean c1ccc2c(c1)ccc(c2O)C(=O)O
FIV
6ZGT
A0LNN5 172.2 Da LogP 2.54 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc2cc(ccc2c1)C(=O)O
HCI
6ZGS
A0LNN5 150.2 Da LogP 1.70 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc(cc1)CCC(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.