Protein profile

VK055_0772

bacterial regulatory helix-turn-helix, lysR family protein

Genome: KpATCC43816

Gene: AIK79395.1 Structure source: ColabFold
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Amino acids 57
Annotations 2
Features 15
PDB binders 0
Druggability 0.241

Overview

Basic information about this protein and its source genome.

Accession
VK055_0772
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79395.1
Status
annotated
Amino acids
57
Structure source
ColabFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
57.143
DEG E-value
3.37e-12
Localization
Cytoplasmic
ColabFold pLDDT
86.37

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.241
Structure CB_VK055_0772
Pocket Pocket 1
P2Rank
Structure CB_VK055_0772
Pocket No pockets
ColabFold model
FPocket 0.241 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 103 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
3 55 Gene3D G3DSA:1.10.10.10 -
3 55 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
7 53 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
7 53 InterPro IPR000847 Transcription regulator HTH, LysR
4 53 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
4 53 InterPro IPR036390 Winged helix DNA-binding domain superfamily
22 33 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
22 33 InterPro IPR000847 Transcription regulator HTH, LysR
33 43 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
33 43 InterPro IPR000847 Transcription regulator HTH, LysR
43 54 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
43 54 InterPro IPR000847 Transcription regulator HTH, LysR
5 53 ProSiteProfiles PS50931 LysR-type HTH domain profile.
5 53 InterPro IPR000847 Transcription regulator HTH, LysR
5 52 PANTHER PTHR30126 HTH-TYPE TRANSCRIPTIONAL REGULATOR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_0772
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.241