Protein profile

VK055_0836

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK79459.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPQ4
Export view
Amino acids 223
Annotations 4
Features 31
PDB binders 0
Druggability 0.871

Overview

Basic information about this protein and its source genome.

Accession
VK055_0836
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79459.1
Status
annotated
Amino acids
223
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0048473 The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.594
DEG E-value
1.34e-37
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.871
Structure A0A0H3GPQ4
Pocket Pocket 5
P2Rank 0.065
Structure A0A0H3GPQ4
Pocket Pocket 1
ColabFold model
FPocket 0.881 · Pocket 5
P2Rank 0.093 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 370 / 4744 genomes with a hit
Normalized 0.078

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0048473 The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
1 21 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
189 211 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 46 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
151 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
111 121 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
140 150 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
57 81 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
122 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 221 Gene3D G3DSA:1.10.3720.10 -
8 221 InterPro IPR035906 MetI-like superfamily
82 86 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
51 221 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
51 221 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
10 222 FunFam G3DSA:1.10.3720.10:FF:000002 D-methionine ABC transporter permease MetI
87 109 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
213 223 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
18 210 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
18 210 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
23 205 CDD cd06261 TM_PBP2
23 205 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
173 192 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
11 205 SUPERFAMILY SSF161098 MetI-like
11 205 InterPro IPR035906 MetI-like superfamily
87 110 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
193 212 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
122 139 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 221 PANTHER PTHR30450 ABC TRANSPORTER PERMEASE
22 45 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
46 56 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
59 81 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPQ4
AlphaFold — — full sequence — Viewing
ColabFold VK055_0836
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.871

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.03 0.006