Protein profile

VK055_0875

helix-turn-helix family protein

Genome: KpATCC43816

Gene: AIK79498.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GT70
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Amino acids 160
Annotations 1
Features 21
PDB binders 0
Druggability 0.685

Overview

Basic information about this protein and its source genome.

Accession
VK055_0875
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79498.1
Status
annotated
Amino acids
160
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
77.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.685
Structure A0A0H3GT70
Pocket Pocket 11
P2Rank 0.07
Structure A0A0H3GT70
Pocket Pocket 1
ColabFold model
FPocket 0.967 · Pocket 15
P2Rank 0.026 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 25 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
120 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 60 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
4 60 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
5 60 CDD cd00093 HTH_XRE
5 60 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
142 160 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
93 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 60 Pfam PF01381 Helix-turn-helix
7 60 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
7 60 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
115 119 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
120 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 92 PANTHER PTHR46558 TRACRIPTIONAL REGULATORY PROTEIN-RELATED-RELATED
6 60 SMART SM00530 mbf_short4
6 60 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
2 69 Gene3D G3DSA:1.10.260.40 -
2 69 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
93 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
81 158 Pfam PF13239 2TM domain
81 158 InterPro IPR025698 2TM domain
1 92 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT70
AlphaFold — — full sequence — Viewing
ColabFold VK055_0875
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.685

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.48 0.127