Protein profile

VK055_0912

universal stress protein UP12

Genome: KpATCC43816

Gene: AIK79535.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPI2
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Amino acids 143
Annotations 0
Features 15
PDB binders 0
Druggability 0.456

Overview

Basic information about this protein and its source genome.

Accession
VK055_0912
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79535.1
Status
annotated
Amino acids
143
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.759
DEG E-value
2.58e-29
Localization
Cytoplasmic
ColabFold pLDDT
89.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.456
Structure A0A0H3GPI2
Pocket Pocket 1
P2Rank 0.217
Structure A0A0H3GPI2
Pocket Pocket 1
ColabFold model
FPocket 0.704 · Pocket 1
P2Rank 0.527 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
1 143 PIRSF PIRSF006276 UspA
1 143 InterPro IPR006015 Universal stress protein A family
1 143 SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like
4 142 CDD cd00293 USP_Like
62 143 PANTHER PTHR46268 STRESS RESPONSE PROTEIN NHAX
2 20 PRINTS PR01438 Universal stress protein signature
2 20 InterPro IPR006015 Universal stress protein A family
104 116 PRINTS PR01438 Universal stress protein signature
104 116 InterPro IPR006015 Universal stress protein A family
121 143 PRINTS PR01438 Universal stress protein signature
121 143 InterPro IPR006015 Universal stress protein A family
1 143 Pfam PF00582 Universal stress protein family
1 143 InterPro IPR006016 UspA
1 143 Gene3D G3DSA:3.40.50.620 HUPs
1 143 InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPI2
AlphaFold — — full sequence — Viewing
ColabFold VK055_0912
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.456
4 0.146
3 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.5 0.217