Protein profile

VK055_0997

corA-like Mg2+ transporter family protein

Genome: KpATCC43816

Gene: AIK79620.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS81
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Amino acids 334
Annotations 9
Features 17
PDB binders 0
Druggability 0.975

Overview

Basic information about this protein and its source genome.

Accession
VK055_0997
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79620.1
Status
annotated
Amino acids
334
Structure source
AlphaFold + ColabFold
GO
GO:0046873 Enables the transfer of metal ions from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030001 The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050897 Binding to a cobalt ion (Co2+).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.975
Structure A0A0H3GS81
Pocket Pocket 3
P2Rank 0.083
Structure A0A0H3GS81
Pocket Pocket 1
ColabFold model
FPocket 0.924 · Pocket 20
P2Rank 0.03 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9
  • GO:0046873 Enables the transfer of metal ions from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0030001 The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0050897 Binding to a cobalt ion (Co2+).
  • GO:0015087 Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0015095 Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
307 328 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
10 263 SUPERFAMILY SSF143865 CorA soluble domain-like
10 263 InterPro IPR045861 CorA, cytoplasmic domain
44 325 Pfam PF01544 CorA-like Mg2+ transporter protein
44 325 InterPro IPR002523 Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB
273 295 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
272 294 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
269 330 SUPERFAMILY SSF144083 Magnesium transport protein CorA, transmembrane region
269 330 InterPro IPR045863 CorA, transmembrane region
43 331 PANTHER PTHR46494 CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)
329 334 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
296 306 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
265 332 Gene3D G3DSA:1.20.58.340 Magnesium transport protein CorA, transmembrane region
4 142 Gene3D G3DSA:3.30.460.20 -
1 272 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
146 264 Gene3D G3DSA:1.20.58.340 Magnesium transport protein CorA, transmembrane region
309 328 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS81
AlphaFold — — full sequence — Viewing
ColabFold VK055_0997
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.975

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.15 0.009