Protein profile

VK055_1064

bacterial regulatory, arsR family protein

Genome: KpATCC43816

Gene: AIK79687.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWK4
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Amino acids 247
Annotations 3
Features 24
PDB binders 0
Druggability 0.415

Overview

Basic information about this protein and its source genome.

Accession
VK055_1064
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79687.1
Status
annotated
Amino acids
247
Structure source
AlphaFold + ColabFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.963
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.415
Structure A0A0H3GWK4
Pocket Pocket 14
P2Rank 0.706
Structure A0A0H3GWK4
Pocket Pocket 1
ColabFold model
FPocket 0.6 · Pocket 5
P2Rank 0.624 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 25 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
71 230 SMART SM01134 DeoRC_2
74 231 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
74 231 InterPro IPR037171 NagB/RpiA transferase-like
1 55 Gene3D G3DSA:1.10.10.10 -
1 55 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
73 220 Gene3D G3DSA:3.40.50.1360 -
6 40 ProSitePatterns PS00894 DeoR-type HTH domain signature.
6 40 InterPro IPR018356 Transcription regulator, HTH DeoR-type, conserved site
26 46 Coils Coil Coil
6 58 SMART SM00420 deor2
6 58 InterPro IPR001034 DeoR-type HTH domain
75 229 Pfam PF00455 DeoR C terminal sensor domain
75 229 InterPro IPR014036 DeoR C-terminal sensor domain
6 62 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
6 62 InterPro IPR036390 Winged helix DNA-binding domain superfamily
6 59 Pfam PF08220 DeoR-like helix-turn-helix domain
6 59 InterPro IPR001034 DeoR-type HTH domain
3 58 ProSiteProfiles PS51000 DeoR-type HTH domain profile.
3 58 InterPro IPR001034 DeoR-type HTH domain
24 38 PRINTS PR00037 LacR bacterial regulatory protein HTH signature
24 38 InterPro IPR001034 DeoR-type HTH domain
38 56 PRINTS PR00037 LacR bacterial regulatory protein HTH signature
38 56 InterPro IPR001034 DeoR-type HTH domain
4 239 PANTHER PTHR30363 HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWK4
AlphaFold — — full sequence — Viewing
ColabFold VK055_1064
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.034
7 0.002
3 0.001
13 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.63 0.706
2 1.86 0.03