Protein profile

VK055_1093

intracellular multiplication and human macrophage-killing family protein

Genome: KpATCC43816

Gene: AIK79716.1 Structure source: AlphaFold + ColabFold UniProt A0A483FSP9
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Amino acids 1082
Annotations 0
Features 11
PDB binders 0
Druggability 0.923

Overview

Basic information about this protein and its source genome.

Accession
VK055_1093
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79716.1
Status
annotated
Amino acids
1082
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
81.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.923
Structure A0A483FSP9
Pocket Pocket 3
P2Rank 0.138
Structure A0A483FSP9
Pocket Pocket 1
ColabFold model
FPocket 0.636 · Pocket 7
P2Rank 0.079 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 28 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
20 1082 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
26 1056 PANTHER PTHR36153 INNER MEMBRANE PROTEIN-RELATED
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
932 1036 Pfam PF06744 Type VI secretion protein IcmF C2-like domain
932 1036 InterPro IPR010623 Type VI secretion system IcmF, C-terminal
3 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
356 673 Pfam PF06761 Intracellular multiplication and human macrophage-killing
356 673 InterPro IPR009612 IcmF-related

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483FSP9
AlphaFold — — full sequence — Viewing
ColabFold VK055_1093
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.923
71 0.9
77 0.875
31 0.202

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.08 0.103
2 1.82 0.034
3 1.49 0.021
4 0.8 0.003