Protein profile

VK055_1099

type VI secretion valine-glycine repeat protein G

Genome: KpATCC43816

Gene: AIK79722.1 vgrG Structure source: ColabFold
Export view
Amino acids 573
Annotations 0
Features 17
PDB binders 0
Druggability 0.424

Overview

Basic information about this protein and its source genome.

Accession
VK055_1099
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79722.1 vgrG
Status
annotated
Amino acids
573
Structure source
ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
62.872
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.98

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.424
Structure CB_VK055_1099
Pocket Pocket 9
P2Rank 0.21
Structure CB_VK055_1099
Pocket Pocket 1
ColabFold model
FPocket 0.424 · Pocket 9
P2Rank 0.21 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 28 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
389 473 Gene3D G3DSA:2.40.50.230 -
389 473 InterPro IPR037026 Vgr protein, OB-fold domain superfamily
26 517 NCBIfam TIGR01646 type VI secretion system tip protein VgrG
26 517 InterPro IPR006533 Type VI secretion system, RhsGE-associated Vgr protein
383 473 SUPERFAMILY SSF69255 gp5 N-terminal domain-like
295 371 Gene3D G3DSA:2.30.110.50 -
14 169 Gene3D G3DSA:2.30.110.50 -
82 195 PANTHER PTHR32305 -
407 474 Pfam PF04717 Type VI secretion system/phage-baseplate injector OB domain
407 474 InterPro IPR006531 Gp5/Type VI secretion system Vgr protein, OB-fold domain
17 516 NCBIfam TIGR03361 type VI secretion system tip protein TssI/VgrG N-terminal domain
17 516 InterPro IPR017847 Type VI secretion system, RhsGE-associated Vgr family subset
493 573 Pfam PF13296 Putative type VI secretion system Rhs element Vgr
493 573 InterPro IPR028244 Putative type VI secretion system, Rhs element associated Vgr domain
203 384 SUPERFAMILY SSF69279 Phage tail proteins
34 355 Pfam PF05954 Phage tail baseplate hub (GPD)
15 192 SUPERFAMILY SSF69279 Phage tail proteins

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_1099
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.077
50 0.077
51 0.037
52 0.004

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.38 0.21
2 5.25 0.201
3 4.49 0.158
4 3.48 0.101
5 3.08 0.082