Protein profile

VK055_1118

glycosyl transferase 2 family protein

Genome: KpATCC43816

Gene: AIK79741.1 Structure source: AlphaFold + ColabFold UniProt A0A2S6EAW8
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Amino acids 605
Annotations 2
Features 27
PDB binders 0
Druggability 0.901

Overview

Basic information about this protein and its source genome.

Accession
VK055_1118
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79741.1
Status
annotated
Amino acids
605
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
34.146
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.901
Structure A0A2S6EAW8
Pocket Pocket 29
P2Rank 0.999
Structure A0A2S6EAW8
Pocket Pocket 1
ColabFold model
FPocket 0.704 · Pocket 36
P2Rank 0.998 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
55 77 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
101 318 Gene3D G3DSA:3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
101 318 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
571 593 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
78 429 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
44 54 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
471 493 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
430 459 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
536 556 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
471 493 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
26 593 PANTHER PTHR43867 CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]
111 454 SUPERFAMILY SSF53448 Nucleotide-diphospho-sugar transferases
111 454 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
21 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
536 558 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 305 Pfam PF00535 Glycosyl transferase family 2
113 305 InterPro IPR001173 Glycosyltransferase 2-like
494 535 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
436 458 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
460 470 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
596 605 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
576 595 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
110 412 CDD cd06421 CESA_CelA_like
557 575 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
55 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2S6EAW8
AlphaFold — — full sequence — Viewing
ColabFold VK055_1118
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
29 0.901
51 0.42

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 105.56 0.996
2 4.33 0.18
3 3.1 0.104
4 2.83 0.088
5 2.74 0.083