Protein profile

VK055_1204

putative alcohol dehydrogenase zinc-binding domain protein

Genome: KpATCC43816

Gene: AIK79827.1 Structure source: ColabFold
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Amino acids 276
Annotations 1
Features 9
PDB binders 0
Druggability 0.512

Overview

Basic information about this protein and its source genome.

Accession
VK055_1204
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79827.1
Status
annotated
Amino acids
276
Structure source
ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
36.134
Human E-value
9.7e-11
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.343
Localization
Unknown
ColabFold pLDDT
95.18

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.512
Structure CB_VK055_1204
Pocket Pocket 9
P2Rank 0.715
Structure CB_VK055_1204
Pocket Pocket 1
ColabFold model
FPocket 0.512 · Pocket 9
P2Rank 0.715 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
11 93 SUPERFAMILY SSF50129 GroES-like
11 93 InterPro IPR011032 GroES-like superfamily
73 247 Gene3D G3DSA:3.40.50.720 -
10 263 Gene3D G3DSA:3.90.180.10 -
8 248 SMART SM00829 PKS_ER_names_mod
8 248 InterPro IPR020843 Polyketide synthase, enoylreductase domain
7 258 PANTHER PTHR43677 SHORT-CHAIN DEHYDROGENASE/REDUCTASE
65 225 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
65 225 InterPro IPR036291 NAD(P)-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_1204
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.215
14 0.142
13 0.016

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.02 0.715
2 12.54 0.57
3 6.27 0.261
4 4.66 0.167
5 3.91 0.125