Metabolic network

VK055_1323

adenylosuccinate lyase

Back to protein
Network centrality 0.39378 top 99.6%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing chokepoint reaction in Alanine, aspartate and glutamate metabolism, no isoenzyme backup detected, more central than 99.6% of genes in this genome.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Alanine, aspartate and glutamate metabolism Purine metabolism

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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Pathway
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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN-15742

EC 4.3.2.- · RXN-15742 · reversible · no isoenzyme backup

4-(beta-D-ribofuranosyl)-N-succinylaminobenzene 5'-phosphate
⇌
4-(beta-D-ribofuranosyl)aminobenzene-5'-phosphate fumarate

AICARSYN-RXN

EC 4.3.2.2 · AICARSYN-RXN · not reversible · no isoenzyme backup

5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
→
fumarate 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

RXN-22497

EC 4.3.2.2 · RXN-22497 · not reversible · no isoenzyme backup

Producing chokepoint
2-amino-2'-deoxy-N6-[(2S)-succino]adenylate
→
dZMP fumarate

AMPSYN-RXN

EC 4.3.2.2 · AMPSYN-RXN · not reversible · no isoenzyme backup

Consuming chokepoint
adenylosuccinate
→
AMP fumarate

Imported from KpATCC43816.sbml · 2026-07-09