KEGG:map00230

Purine metabolism

KpATCC43816 - Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

All pathways Protein ranking
Reactions 71
Proteins 42
Metabolites 83
Chokepoints 15

Pathway map

Reaction-to-metabolite flow reconstructed from the imported SBML participants.

Chokepoint reaction Metabolite ⇌ Reversible reaction Currency metabolites hidden
Computing layout…

Graph capped for readability; 26 additional reactions are listed below.

Connected pathways

Other pathways in this genome that share reactions with this one.

MODEL Unassigned metabolic reactions 209 shared KEGG Pentose phosphate pathway 23 shared KEGG Pyrimidine metabolism 18 shared KEGG Cysteine and methionine metabolism 12 shared KEGG Histidine metabolism 7 shared KEGG Porphyrin metabolism 4 shared KEGG One carbon pool by folate 4 shared KEGG Glycine, serine and threonine metabolism 4 shared KEGG Glyoxylate and dicarboxylate metabolism 4 shared KEGG Alanine, aspartate and glutamate metabolism 4 shared KEGG Phosphonate and phosphinate metabolism 4 shared KEGG Arginine biosynthesis 3 shared KEGG Folate biosynthesis 2 shared KEGG Citrate cycle (TCA cycle) 2 shared KEGG Riboflavin metabolism 1 shared KEGG Sulfur metabolism 1 shared KEGG Propanoate metabolism 1 shared KEGG Valine, leucine and isoleucine degradation 1 shared

Reaction table

Catalyzed reactions, mapped genes, and SBML substrates/products.

ADDALT-RXN

EC 3.5.4.4 · R02556 · ADDALT-RXN · not reversible

2'-deoxyadenosine H+ H2O
→
2'-deoxyinosine ammonium
VK055_0519

AICARSYN-RXN

EC 4.3.2.2 · R04559 · AICARSYN-RXN · not reversible

5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
→
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide fumarate
VK055_1323

AICARTRANSFORM-RXN

EC 2.1.2.3 · R04560 · AICARTRANSFORM-RXN · not reversible

both
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide an N10-formyltetrahydrofolate
→
5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide a tetrahydrofolate
VK055_3086

AIRS-RXN

EC 6.3.3.1 · R04208 · AIRS-RXN · not reversible

both
2-(formamido)-N1-(5-phospho-beta-D-ribosyl)acetamidine ATP
→
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole ADP H+ phosphate
VK055_4686

DEOXYADENOSINE-KINASE-RXN

EC 2.7.1.145, 2.7.1.74, 2.7.1.76 · R02089 · DEOXYADENOSINE-KINASE-RXN · not reversible

2'-deoxyadenosine ATP
→
dAMP ADP H+
No mapped protein

DEOXYGUANOSINE-KINASE-RXN

EC 2.7.1.113, 2.7.1.145, 2.7.1.74 · R01967 · DEOXYGUANOSINE-KINASE-RXN · not reversible

2'-deoxyguanosine ATP
→
dGMP ADP H+
No mapped protein

FGAMSYN-RXN

EC 6.3.5.3 · R04463 · FGAMSYN-RXN · not reversible

both
L-glutamine N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide ATP H2O
→
2-(formamido)-N1-(5-phospho-beta-D-ribosyl)acetamidine L-glutamate ADP H+ phosphate
VK055_4619

GARTRANSFORMYL2-RXN

EC 6.3.1.21 · R06974 · GARTRANSFORMYL2-RXN · not reversible

N1-(5-phospho-beta-D-ribosyl)glycinamide formate ATP
→
N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide ADP H+ phosphate
VK055_0084

GART-RXN

EC 2.1.2.2 · R04325 · GART-RXN · not reversible

N1-(5-phospho-beta-D-ribosyl)glycinamide an N10-formyltetrahydrofolate
→
N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide a tetrahydrofolate H+
VK055_4685

GLYRIBONUCSYN-RXN

EC 6.3.4.13 · R04144 · GLYRIBONUCSYN-RXN · not reversible

both
5-phospho-beta-D-ribosylamine glycine ATP
→
N1-(5-phospho-beta-D-ribosyl)glycinamide ADP H+ phosphate
VK055_3088

GTPPYPHOSKIN-RXN

EC 2.7.6.5 · R00429 · GTPPYPHOSKIN-RXN · not reversible

ATP GTP
→
pppGpp AMP H+
No mapped protein

PPPGPPHYDRO-RXN

EC 3.6.1.40 · R03409 · PPPGPPHYDRO-RXN · not reversible

pppGpp H2O
→
ppGpp H+ phosphate
No mapped protein

PRPPAMIDOTRANS-RXN

EC 2.4.2.14 · R01072 · PRPPAMIDOTRANS-RXN · not reversible

producing
5-phospho-alpha-D-ribose 1-diphosphate L-glutamine H2O
→
5-phospho-beta-D-ribosylamine L-glutamate diphosphate
VK055_4811

PRPPSYN-RXN

EC 2.7.6.1 · R01049 · PRPPSYN-RXN · not reversible

D-ribose 5-phosphate ATP
→
5-phospho-alpha-D-ribose 1-diphosphate AMP H+
VK055_0212

RXN0-1441

EC 3.6.1.13, 3.6.1.53 · R01054 · RXN0-1441 · not reversible

ADP-D-ribose H2O
→
D-ribofuranose 5-phosphate AMP H+
VK055_4026

RXN0-5199

EC 2.4.2.1, 2.4.2.15 · R02147 · RXN0-5199 · reversible

guanosine phosphate
⇌
alpha-D-ribose-1-phosphate guanine
VK055_2591

RXN0-742

EC 6.3.4.18 · R07404 · RXN0-742 · not reversible

both
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole hydrogen carbonate ATP
→
N5-carboxyaminoimidazole ribonucleotide ADP H+ phosphate
VK055_2070

RXN0-743

EC 5.4.99.18 · R07405 · RXN0-743 · not reversible

both
N5-carboxyaminoimidazole ribonucleotide
→
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
VK055_2069

RXN0-901

EC 1.17.1.4 · R02103 · RXN0-901 · reversible

xanthine H2O NAD+
⇌
urate H+ NADH
No mapped protein

RXN-11186

EC 1.14.13.113 · R09514 · RXN-11186 · not reversible

urate H+ NADH dioxygen
→
(S)-5-hydroxyisourate H2O NAD+
No mapped protein

RXN-14270

EC 2.4.2.7 · R04378 · RXN-14270 · not reversible

5-amino-4-imidazolecarboxyamide 5-phospho-alpha-D-ribose 1-diphosphate
→
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide diphosphate
VK055_2098

RXN-6201

EC 4.1.1.97 · R06604 · RXN-6201 · not reversible

(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline H+
→
(S)-(+)-allantoin CO2
No mapped protein

RXN-7682

EC 1.17.1.4 · R01768 · RXN-7682 · not reversible

hypoxanthine H2O NAD+
→
xanthine H+ NADH
No mapped protein

SAICARSYN-RXN

EC 6.3.2.6 · R04591 · SAICARSYN-RXN · not reversible

both
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate L-aspartate ATP
→
5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole ADP H+ phosphate
VK055_4701

XANPRIBOSYLTRAN-RXN

EC 2.4.2.22 · R02142 · XANPRIBOSYLTRAN-RXN · not reversible

5-phospho-alpha-D-ribose 1-diphosphate xanthine
→
XMP diphosphate
No mapped protein