Protein profile

VK055_1396

rhodanese-like domain protein

Genome: KpATCC43816

Gene: AIK80020.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVF7
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Amino acids 354
Annotations 3
Features 19
PDB binders 0
Druggability 0.87

Overview

Basic information about this protein and its source genome.

Accession
VK055_1396
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80020.1
Status
annotated
Amino acids
354
Structure source
AlphaFold + ColabFold
EC
1.14.-.-
GO
GO:0016705 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0006400 The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.25
Human E-value
4.4e-31
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
33.793
Localization
Cytoplasmic
ColabFold pLDDT
90.7

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87
Structure A0A0H3GVF7
Pocket Pocket 1
P2Rank 0.881
Structure A0A0H3GVF7
Pocket Pocket 1
ColabFold model
FPocket 0.028 · Pocket 1
P2Rank 0.851 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016705 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
  • GO:0006400 The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
12 118 Gene3D G3DSA:3.30.70.100 -
136 237 SMART SM00450 rhod_4
136 237 InterPro IPR001763 Rhodanese-like domain
115 257 SUPERFAMILY SSF52821 Rhodanese/Cell cycle control phosphatase
115 257 InterPro IPR036873 Rhodanese-like domain superfamily
246 307 Pfam PF12368 Rhodanase C-terminal
246 307 InterPro IPR022111 Rhodanase, C-terminal
133 233 CDD cd01518 RHOD_YceA
1 340 PANTHER PTHR43846 UPF0176 PROTEIN YCEA
25 117 Pfam PF17773 UPF0176 acylphosphatase like domain
25 117 InterPro IPR040503 tRNA uridine(34) hydroxylase, N-terminal
22 277 Hamap MF_00469 tRNA uridine(34) hydroxylase [trhO].
22 277 InterPro IPR020936 tRNA uridine(34) hydroxylase
125 270 Gene3D G3DSA:3.40.250.10 -
125 270 InterPro IPR036873 Rhodanese-like domain superfamily
138 232 Pfam PF00581 Rhodanese-like domain
138 232 InterPro IPR001763 Rhodanese-like domain
146 240 ProSiteProfiles PS50206 Rhodanese domain profile.
146 240 InterPro IPR001763 Rhodanese-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVF7
AlphaFold — — full sequence — Viewing
ColabFold VK055_1396
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.87
23 0.341

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.08 0.795
2 1.88 0.037
3 1.76 0.032
4 1.64 0.027
5 1.57 0.024