Protein profile

VK055_1498

transcriptional coactivator for CRP

Genome: KpATCC43816

Gene: AIK80118.1 sxy Structure source: AlphaFold + ColabFold UniProt A0A0H3GL50
Export view
Amino acids 205
Annotations 1
Features 11
PDB binders 0
Druggability 0.175

Overview

Basic information about this protein and its source genome.

Accession
VK055_1498
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80118.1 sxy
Status
annotated
Amino acids
205
Structure source
AlphaFold + ColabFold
GO
GO:0030420 The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
33.158
Localization
Unknown
ColabFold pLDDT
87.47

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.175
Structure A0A0H3GL50
Pocket Pocket 8
P2Rank
Structure A0A0H3GL50
Pocket No pockets
ColabFold model
FPocket 0.589 · Pocket 5
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 49 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0030420 The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
23 112 Pfam PF04993 TfoX N-terminal domain
23 112 InterPro IPR007076 TfoX, N-terminal
8 205 PIRSF PIRSF028788 TfoX_Sxy
8 205 InterPro IPR026256 DNA transformation protein TfoX-like, gammaproteobacteria
15 114 Gene3D G3DSA:3.30.1460.30 -
124 201 Pfam PF04994 TfoX C-terminal domain
124 201 InterPro IPR007077 TfoX, C-terminal
18 203 PANTHER PTHR36121 PROTEIN SXY
18 203 InterPro IPR047525 DNA transformation protein TfoX-like
18 114 SUPERFAMILY SSF159894 YgaC/TfoX-N like
122 205 Gene3D G3DSA:1.10.150.20 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GL50
AlphaFold — — full sequence — Viewing
ColabFold VK055_1498
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer