Protein profile

VK055_1530

hypothetical protein

Genome: KpATCC43816

Gene: AIK80150.1 Structure source: AlphaFold + ColabFold UniProt A0A422WDQ5
Export view
Amino acids 183
Annotations 4
Features 17
PDB binders 0
Druggability 0.381

Overview

Basic information about this protein and its source genome.

Accession
VK055_1530
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80150.1
Status
annotated
Amino acids
183
Structure source
AlphaFold + ColabFold
GO
GO:0046872 Binding to a metal ion. GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.257
DEG E-value
1.6200000000000002e-123
Localization
Unknown
ColabFold pLDDT
88.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.381
Structure A0A422WDQ5
Pocket Pocket 1
P2Rank 0.701
Structure A0A422WDQ5
Pocket Pocket 1
ColabFold model
FPocket 0.304 · Pocket 3
P2Rank 0.791 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0046872 Binding to a metal ion.
  • GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
2 183 PANTHER PTHR37425 -
2 183 InterPro IPR010275 Protein of unknown function DUF882
34 183 Pfam PF05951 Bacterial protein of unknown function (DUF882)
34 183 InterPro IPR010275 Protein of unknown function DUF882
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
11 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 31 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 31 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
67 183 SUPERFAMILY SSF55166 Hedgehog/DD-peptidase
67 183 InterPro IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
23 31 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
64 183 Gene3D G3DSA:3.30.1380.10 -
64 183 InterPro IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
32 183 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 31 Phobius SIGNAL_PEPTIDE Signal peptide region
76 183 CDD cd14844 Zn-DD-carboxypeptidase_like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A422WDQ5
AlphaFold — — full sequence — Viewing
ColabFold VK055_1530
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.069
7 0.025
2 0.009
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.44 0.701
2 1.14 0.008