Protein profile

VK055_1545

integration host factor, beta subunit

Genome: KpATCC43816

Gene: ihfB AIK80165.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQN5
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Amino acids 95
Annotations 7
Features 22
PDB binders 0
Druggability 0.367

Overview

Basic information about this protein and its source genome.

Accession
VK055_1545
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
ihfB AIK80165.1
Status
annotated
Amino acids
95
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin. GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
56.701
DEG E-value
2.9800000000000002e-33
Localization
Cytoplasmic
ColabFold pLDDT
97.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.367
Structure A0A0H3GQN5
Pocket Pocket 5
P2Rank 0.002
Structure A0A0H3GQN5
Pocket Pocket 1
ColabFold model
FPocket 0.75 · Pocket 4
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 225 / 4744 genomes with a hit
Normalized 0.047

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.
  • GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
41 56 PRINTS PR01727 Prokaryotic integration host factor signature
41 56 InterPro IPR000119 Histone-like DNA-binding protein
59 72 PRINTS PR01727 Prokaryotic integration host factor signature
59 72 InterPro IPR000119 Histone-like DNA-binding protein
75 89 PRINTS PR01727 Prokaryotic integration host factor signature
75 89 InterPro IPR000119 Histone-like DNA-binding protein
1 94 NCBIfam TIGR00988 integration host factor subunit beta
1 94 InterPro IPR005685 Integration host factor, beta subunit
1 90 PANTHER PTHR33175 DNA-BINDING PROTEIN HU
1 90 InterPro IPR000119 Histone-like DNA-binding protein
1 91 SMART SM00411 bhlneu
1 91 InterPro IPR000119 Histone-like DNA-binding protein
1 89 CDD cd13836 IHF_B
1 94 Gene3D G3DSA:4.10.520.10 -
1 94 InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
1 94 Hamap MF_00381 Integration host factor subunit beta [ihfB].
1 91 SUPERFAMILY SSF47729 IHF-like DNA-binding proteins
1 91 InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
47 66 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature.
47 66 InterPro IPR020816 Histone-like DNA-binding protein, conserved site
1 94 FunFam G3DSA:4.10.520.10:FF:000003 Integration host factor subunit beta
1 91 Pfam PF00216 Bacterial DNA-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQN5
AlphaFold — — full sequence — Viewing
ColabFold VK055_1545
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.367
1 0.015
3 0.009
2 0.005

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.8 0.002