Protein profile

VK055_1601

potI

Genome: KpATCC43816

Gene: AIK80221.1 potI Structure source: AlphaFold + ColabFold UniProt A0A0H3GM52
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Amino acids 281
Annotations 2
Features 33
PDB binders 0
Druggability 0.931

Overview

Basic information about this protein and its source genome.

Accession
VK055_1601
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80221.1 potI
Status
annotated
Amino acids
281
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.87
DEG E-value
1.44e-59
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.931
Structure A0A0H3GM52
Pocket Pocket 14
P2Rank 0.023
Structure A0A0H3GM52
Pocket Pocket 1
ColabFold model
FPocket 0.902 · Pocket 19
P2Rank 0.167 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 147 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
233 243 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 35 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
8 266 SUPERFAMILY SSF161098 MetI-like
8 266 InterPro IPR035906 MetI-like superfamily
164 183 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
207 211 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
141 163 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
184 206 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
82 256 CDD cd06261 TM_PBP2
82 256 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
69 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
11 272 Gene3D G3DSA:1.10.3720.10 -
11 272 InterPro IPR035906 MetI-like superfamily
265 281 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
102 129 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
244 264 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
130 140 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
212 232 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
60 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
242 264 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
184 206 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
11 271 FunFam G3DSA:1.10.3720.10:FF:000040 Putrescine ABC transporter, permease protein PotI
91 101 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
81 273 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
81 273 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
141 163 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
65 260 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
65 260 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
8 275 PANTHER PTHR43848 PUTRESCINE TRANSPORT SYSTEM PERMEASE PROTEIN POTI
36 59 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GM52
AlphaFold — — full sequence — Viewing
ColabFold VK055_1601
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.931
4 0.533
22 0.356