Protein profile

VK055_1602

potH

Genome: KpATCC43816

Gene: AIK80222.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQJ0
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Amino acids 317
Annotations 3
Features 31
PDB binders 0
Druggability 0.705

Overview

Basic information about this protein and its source genome.

Accession
VK055_1602
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80222.1
Status
annotated
Amino acids
317
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
35.648
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.7

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.705
Structure A0A0H3GQJ0
Pocket Pocket 6
P2Rank 0.106
Structure A0A0H3GQJ0
Pocket Pocket 1
ColabFold model
FPocket 0.808 · Pocket 2
P2Rank 0.293 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 135 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
99 305 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
99 305 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
185 207 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 313 Gene3D G3DSA:1.10.3720.10 -
29 313 InterPro IPR035906 MetI-like superfamily
306 317 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
228 253 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
284 305 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 312 FunFam G3DSA:1.10.3720.10:FF:000043 Putrescine ABC transporter permease PotH
134 155 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
132 154 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
208 227 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
185 207 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
103 122 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
99 299 CDD cd06261 TM_PBP2
99 299 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
23 313 PANTHER PTHR42929 INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCU-RELATED-RELATED
53 102 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
284 306 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 52 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
123 133 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
228 250 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 52 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
254 283 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 30 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
117 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
117 313 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
29 308 SUPERFAMILY SSF161098 MetI-like
29 308 InterPro IPR035906 MetI-like superfamily
156 184 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQJ0
AlphaFold — — full sequence — Viewing
ColabFold VK055_1602
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.705
16 0.382
4 0.303
18 0.207

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.31 0.178
2 3.75 0.144
3 1.41 0.018
4 1.25 0.012