Protein profile

VK055_1646

AAA ATPase domain protein

Genome: KpATCC43816

Gene: AIK80266.1 Structure source: ColabFold
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Amino acids 377
Annotations 2
Features 11
PDB binders 0
Druggability 0.637

Overview

Basic information about this protein and its source genome.

Accession
VK055_1646
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80266.1
Status
annotated
Amino acids
377
Structure source
ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.52

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.637
Structure CB_VK055_1646
Pocket Pocket 13
P2Rank 0.057
Structure CB_VK055_1646
Pocket Pocket 1
ColabFold model
FPocket 0.637 · Pocket 13
P2Rank 0.057 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
27 321 Pfam PF13304 AAA domain, putative AbiEii toxin, Type IV TA system
27 321 InterPro IPR003959 ATPase, AAA-type, core
1 350 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
1 350 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 343 Gene3D G3DSA:3.40.50.300 -
1 343 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
201 353 PIRSF PIRSF029347 RecF
201 353 InterPro IPR014555 RecF-like
1 172 PIRSF PIRSF029347 RecF
1 172 InterPro IPR014555 RecF-like
3 79 PANTHER PTHR40396 ATPASE-LIKE PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_1646
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.003
2 0.002
5 0.001
3 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.51 0.057
2 1.71 0.025