Protein profile

VK055_1690

amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein

Genome: KpATCC43816

Gene: AIK80310.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUH5
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Amino acids 219
Annotations 6
Features 31
PDB binders 0
Druggability 0.697

Overview

Basic information about this protein and its source genome.

Accession
VK055_1690
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80310.1
Status
annotated
Amino acids
219
Structure source
AlphaFold + ColabFold
GO
GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
94.521
DEG E-value
5.58e-148
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.49

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.697
Structure A0A0H3GUH5
Pocket Pocket 16
P2Rank 0.068
Structure A0A0H3GUH5
Pocket Pocket 1
ColabFold model
FPocket 0.897 · Pocket 12
P2Rank 0.045 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 110 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
92 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 209 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
19 209 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
33 217 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
33 217 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
13 202 SUPERFAMILY SSF161098 MetI-like
13 202 InterPro IPR035906 MetI-like superfamily
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
151 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
44 54 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
90 108 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
23 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 111 NCBIfam TIGR01726 ABC transporter permease subunit, His/Glu/Gln/Arg/opine family, N-terminal region
12 111 InterPro IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain
109 150 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
55 78 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 218 Gene3D G3DSA:1.10.3720.10 -
1 218 InterPro IPR035906 MetI-like superfamily
187 209 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 217 PANTHER PTHR30614 MEMBRANE COMPONENT OF AMINO ACID ABC TRANSPORTER
14 217 InterPro IPR043429 ABC transporter membrane protein permease protein ArtM/GltK/GlnP/TcyL/YhdX-like
190 209 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
171 189 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
210 219 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 218 FunFam G3DSA:1.10.3720.10:FF:000011 Glutamine ABC transporter permease GlnP
19 207 CDD cd06261 TM_PBP2
19 207 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 22 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
79 89 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
55 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUH5
AlphaFold — — full sequence — Viewing
ColabFold VK055_1690
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.697
1 0.286
6 0.272
11 0.254

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.08 0.103