Protein profile

VK055_1711

ABC-2 type transporter family protein

Genome: KpATCC43816

Gene: AIK80331.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKB5
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Amino acids 368
Annotations 4
Features 31
PDB binders 0
Druggability 0.787

Overview

Basic information about this protein and its source genome.

Accession
VK055_1711
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80331.1
Status
annotated
Amino acids
368
Structure source
AlphaFold + ColabFold
GO
GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359 Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.99

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.787
Structure A0A0H3GKB5
Pocket Pocket 5
P2Rank 0.076
Structure A0A0H3GKB5
Pocket Pocket 1
ColabFold model
FPocket 0.574 · Pocket 17
P2Rank 0.18 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 103 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0140359 Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
364 368 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
341 363 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 359 Pfam PF12698 ABC-2 family transporter protein
25 359 InterPro IPR013525 ABC-2 type transporter, transmembrane domain
24 46 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
284 303 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
290 309 PRINTS PR00164 ABC-2 type transport system membrane protein signature
290 309 InterPro IPR000412 ABC-2 transporter
310 329 PRINTS PR00164 ABC-2 type transport system membrane protein signature
310 329 InterPro IPR000412 ABC-2 transporter
253 277 PRINTS PR00164 ABC-2 type transport system membrane protein signature
253 277 InterPro IPR000412 ABC-2 transporter
218 243 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
40 168 Gene3D G3DSA:3.40.1710.10 -
278 283 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
173 195 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
244 254 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 364 PANTHER PTHR30294 MEMBRANE COMPONENT OF ABC TRANSPORTER YHHJ-RELATED
284 302 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
340 363 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
255 277 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
198 217 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
223 245 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
303 339 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
173 197 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
255 277 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 41 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
129 366 ProSiteProfiles PS51012 ABC transporter integral membrane type-2 domain profile.
129 366 InterPro IPR047817 ABC-2 type transporter, transmembrane domain, bacterial-type
42 172 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKB5
AlphaFold — — full sequence — Viewing
ColabFold VK055_1711
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.787
10 0.355
28 0.352

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.09 0.104
2 2.47 0.068
3 2.27 0.057
4 1.61 0.026
5 1.52 0.022