Protein profile

VK055_1716

inhibitor of apoptosis-promoting Bax1 family protein

Genome: KpATCC43816

Gene: AIK80336.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKB3
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Amino acids 214
Annotations 1
Features 27
PDB binders 0
Druggability 0.907

Overview

Basic information about this protein and its source genome.

Accession
VK055_1716
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80336.1
Status
annotated
Amino acids
214
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
27.619
Human E-value
3.97e-11
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.907
DEG E-value
6.33e-48
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.907
Structure A0A0H3GKB3
Pocket Pocket 1
P2Rank 0.709
Structure A0A0H3GKB3
Pocket Pocket 1
ColabFold model
FPocket 0.916 · Pocket 7
P2Rank 0.814 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 240 / 4744 genomes with a hit
Normalized 0.051

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
147 166 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
68 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 57 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 111 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
58 68 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
123 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
187 210 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
145 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
211 214 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34 38 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
93 111 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
69 87 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
112 122 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
88 92 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 210 Pfam PF01027 Inhibitor of apoptosis-promoting Bax1
1 210 InterPro IPR006214 Bax inhibitor 1-related
3 212 PANTHER PTHR23291 BAX INHIBITOR-RELATED
3 212 InterPro IPR006214 Bax inhibitor 1-related
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
118 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 211 CDD cd10432 BI-1-like_bacterial
37 56 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
187 209 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
142 146 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
167 186 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKB3
AlphaFold — — full sequence — Viewing
ColabFold VK055_1716
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.907

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.65 0.758
2 7.52 0.396
3 4.5 0.192
4 2.76 0.084
5 2.3 0.059