Protein profile

VK055_1718

molybdopterin converting factor, subunit 1

Genome: KpATCC43816

Gene: moaD AIK80338.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLS7
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Amino acids 82
Annotations 1
Features 11
PDB binders 0
Druggability 0.177

Overview

Basic information about this protein and its source genome.

Accession
VK055_1718
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
moaD AIK80338.1
Status
annotated
Amino acids
82
Structure source
AlphaFold + ColabFold
GO
GO:0006777 The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.98

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.177
Structure A0A0H3GLS7
Pocket Pocket 1
P2Rank
Structure A0A0H3GLS7
Pocket No pockets
ColabFold model
FPocket 0.149 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 150 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0006777 The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
4 82 Pfam PF02597 ThiS family
4 82 InterPro IPR003749 Sulfur carrier ThiS/MoaD-like
1 82 FunFam G3DSA:3.10.20.30:FF:000010 Molybdopterin synthase sulfur carrier subunit
1 82 Gene3D G3DSA:3.10.20.30 -
1 82 InterPro IPR012675 Beta-grasp domain superfamily
2 82 CDD cd00754 Ubl_MoaD
2 82 PANTHER PTHR33359 MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT
2 82 InterPro IPR044672 Molybdopterin synthase sulfur carrier subunit
1 82 SUPERFAMILY SSF54285 MoaD/ThiS
1 82 InterPro IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp
2 82 NCBIfam TIGR01682 molybdopterin converting factor subunit 1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLS7
AlphaFold — — full sequence — Viewing
ColabFold VK055_1718
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer