Protein profile

VK055_1724

transcriptional regulatory protein BasR

Genome: KpATCC43816

Gene: AIK80344.1 basR Structure source: Experimental + ColabFold UniProt A0A0R4I965
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Amino acids 223
Annotations 8
Features 27
PDB binders 2
Druggability 0.981

Overview

Basic information about this protein and its source genome.

Accession
VK055_1724
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80344.1 basR
Status
annotated
Amino acids
223
Structure source
Experimental + ColabFold
GO
GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.304
DEG E-value
3.18e-54
Localization
Cytoplasmic
ColabFold pLDDT
87.74

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.981
Structure 8JO2
Pocket Pocket 1
P2Rank 0.428
Structure 8JO2
Pocket Pocket 1
ColabFold model
FPocket 0.613 · Pocket 1
P2Rank 0.03 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 91 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0046872 Binding to a metal ion.
  • GO:0000156 Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
86 118 Gene3D G3DSA:6.10.250.690 -
3 113 Pfam PF00072 Response regulator receiver domain
3 113 InterPro IPR001789 Signal transduction response regulator, receiver domain
118 217 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
118 217 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
3 117 CDD cd17624 REC_OmpR_PmrA-like
121 223 Gene3D G3DSA:1.10.10.10 -
121 223 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
147 216 Pfam PF00486 Transcriptional regulatory protein, C terminal
147 216 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
1 85 Gene3D G3DSA:3.40.50.2300 -
105 125 Coils Coil Coil
1 112 SMART SM00448 REC_2
1 112 InterPro IPR001789 Signal transduction response regulator, receiver domain
120 218 FunFam G3DSA:1.10.10.10:FF:000005 Two-component system response regulator
145 216 SMART SM00862 Trans_reg_C_3
145 216 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
2 116 ProSiteProfiles PS50110 Response regulatory domain profile.
2 116 InterPro IPR001789 Signal transduction response regulator, receiver domain
132 216 CDD cd00383 trans_reg_C
132 216 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
124 218 ProSiteProfiles PS51755 OmpR/PhoB-type DNA-binding domain profile.
124 218 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
1 218 PANTHER PTHR48111 REGULATOR OF RPOS
1 218 InterPro IPR039420 Transcriptional regulatory protein WalR-like
1 134 SUPERFAMILY SSF52172 CheY-like
1 134 InterPro IPR011006 CheY-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4S04
X-ray 3.20 Å A,B,E,F
100.0% 1-223
PDBe RCSB PDBj File
Viewing
PDB 4S05
X-ray 3.80 Å A,B
100.0% 1-223
PDBe RCSB PDBj File
Loaded
PDB 8JO2
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Loaded
ColabFold VK055_1724
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
64 0.526
52 0.497
8 0.272

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.47 0.327
2 4.28 0.177
3 3.18 0.108
4 2.52 0.07
5 2.14 0.05

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
BEF
4S04 3.20 Å Open crystal
66.0 Da LogP 0.88 TPSA 0.0 ✓ Ro5 ✓ Clean [Be-](F)(F)F

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.