Protein profile

VK055_1749

bacterial regulatory, luxR family protein

Genome: KpATCC43816

Gene: AIK80369.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUA0
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Amino acids 184
Annotations 2
Features 22
PDB binders 0
Druggability 0.579

Overview

Basic information about this protein and its source genome.

Accession
VK055_1749
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80369.1
Status
annotated
Amino acids
184
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.579
Structure A0A0H3GUA0
Pocket Pocket 1
P2Rank 0.126
Structure A0A0H3GUA0
Pocket Pocket 1
ColabFold model
FPocket 0.303 · Pocket 6
P2Rank 0.205 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 8 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
117 131 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
117 131 InterPro IPR000792 Transcription regulator LuxR, C-terminal
131 147 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
131 147 InterPro IPR000792 Transcription regulator LuxR, C-terminal
147 159 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
147 159 InterPro IPR000792 Transcription regulator LuxR, C-terminal
39 184 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
116 166 Pfam PF00196 Bacterial regulatory proteins, luxR family
116 166 InterPro IPR000792 Transcription regulator LuxR, C-terminal
1 19 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
20 38 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
88 176 Gene3D G3DSA:1.10.10.10 -
88 176 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
110 175 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
110 175 InterPro IPR000792 Transcription regulator LuxR, C-terminal
131 158 ProSitePatterns PS00622 LuxR-type HTH domain signature.
131 158 InterPro IPR000792 Transcription regulator LuxR, C-terminal
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
114 171 SMART SM00421 luxrmega5
114 171 InterPro IPR000792 Transcription regulator LuxR, C-terminal
107 170 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
107 170 InterPro IPR016032 Signal transduction response regulator, C-terminal effector

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUA0
AlphaFold — — full sequence — Viewing
ColabFold VK055_1749
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.408
5 0.03
6 0.001
2 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.93 0.126
2 1.4 0.014